To the Editor: I wish to report the case of an 18-year-old woman in whom juvenile rheumatoid arthritis developed at the age of 12 years; she was treated with salicylates and intermittent low-dose steroids. Because of a mild elevation in serum aspartate aminotransferase noted three months before admission to the hospital, the salicylates were stopped, and prednisone (7.5 mg per day) added. The aspartate aminotransferase returned to normal, and she was taking no drugs other than prednisone until 14 days before admission; sulindac (Clinoril) was then added in a dosage of 200 mg twice a day. Seven days later, she . . .