Conversion of Δ5-Androstene-3β,16α,17β-Triol to Estriol by Human Placenta1
- 1 September 1958
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 63 (3), 392-394
- https://doi.org/10.1210/endo-63-3-392
Abstract
The in vitro conversion of Δ5-androstene-3β,16α,17β-triol to estriol by human placental preparations has been described. Estriol was characterized by determining several physical constants of the isolated product and its methyl ether, as well as by a positive Bachman reaction. This unique conversion suggests a biological role for the neutral 16-hydroxylated steroids previously isolated from human urine and lends support to the concept of a biosynthetic pathway for estriol not involving known estrogen precursors.Keywords
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