A 13C spin‐lattice relaxation study of dipeptides containing glycine and proline: Mobility of the cyclic proline side chain
- 1 May 1975
- journal article
- research article
- Published by Wiley in Biopolymers
- Vol. 14 (5), 927-935
- https://doi.org/10.1002/bip.1975.360140504
Abstract
Molecular dynamics of the cyclic dipeptides cyclo(Gly‐L‐Pro), cyclo‐(L‐Pro‐L‐Pro), and cyclo(L‐Pro‐D‐Pro) and the linear dipeptides L‐Pro‐Gly and cis and trans Gly‐L‐Pro were studied in neutral aqueous solution by 13C nuclear magnetic resonance. Spinlattice relaxation times (T1) were determined for each individual carbon atom. The correlation times, τ, were derived from a semiquantitative analysis of the T1 data. The correlation times of the proline ring carbons, β, γ, and δ suggest that the cyclic dipeptides have more restriction of conformational freedom in the proline ring than the linear dipeptides. This effect is most pronounced on the γ carbon.This publication has 21 references indexed in Scilit:
- Carbon-13 nuclear magnetic resonance studies of structure and function in thyrotropin-releasing factor. Determination of the tautomeric form of histidine and relation to biology activityBiochemistry, 1974
- Conformation flexibility of the neurohypophyseal hormones oxytocin and lysine-vasopressin. Carbon-13 spin-lattice relaxation study of backbone and side chainsJournal of the American Chemical Society, 1974
- Molecular mobility of polypeptides containing proline as determined by 13C magnetic resonanceBiopolymers, 1974
- Intramolecular motion in peptides determined by 13C NMR: A spin‐lattice relaxation time‐study on MSH‐release‐inhibiting factorFEBS Letters, 1973
- Cyclic peptides. VI. Europium-assisted nuclear magnetic resonance study of the solution conformations of cyclo(L-Pro-L-Pro) and cyclo(L-Pro-D-Pro)Journal of the American Chemical Society, 1973
- Determination of rotational mobilities of backbone and side-chain carbons of poly(γ-benzyl L-glutamate) in the helical and random-coil states from measurements of carbon-13 relaxation times and nuclear Overhauser enhancementsBiochemistry, 1973
- Comparisons of the Carbon-13 Nuclear Magnetic Resonance Spectra of Some Solid cis- and trans-PolyisoprenesMacromolecules, 1972
- STUDIES ON THE CONFORMATION OF AMINO ACIDSInternational Journal of Protein Research, 1971
- Poly(L-proline) II Ring Conformations Determined by Nuclear Magnetic ResonanceMacromolecules, 1971
- The crystal structure of L -leucyl- L -prolylglycineActa Crystallographica, 1958