ARYLAZIDO AMINOPROPIONYL ATP (ANAPP3) ANTAGONISM OF CAT URINARY BLADDER CONTRACTIONS

Abstract

ANAPP3 [arylazidoaminopropionyl ATP] produces a transient contraction of the urinary bladder of the cat similar to that produced by ATP and hypogastric nerve stimulation. ANAPP3 partially antagonizes the inhibition of pelvic nerve-evoked bladder contractions induced by adenosine, possibly by blocking P1 receptors. ANAPP3 antagonizes contractions of the cat urinary bladder induced by ATP, .beta., .gamma.-methylene ATP, pelvic nerve stimulation and hypogastric nerve stimulation. ANAPP3 produces no antagonism of noradrenaline[norepinephrine]-induced inhibition of pelvic nerve-evoked bladder contractions or acetylcholine-induced bladder contractions, thereby substantiating the specificity of the effect of ANAPP3 against purines.