Experimental Study of Acquired Resistance of the Rabbit's Renal Epithelium to Mercuric Chloride

Abstract

Local corrosive action and irregularity of absorption after subcutaneous administration, the danger of thrombosis following intravenous injection, and excretion by the intestine resulting in severe enterocolitis, make HgCl2 an undesirable substance to use in the experimental production of immunity in renal epithelium. In rabbits the amount of HgCl2 absorbed varies greatly. In some, several injections may be given without producing any marked change in the renal epithelium, while in others the same quantity causes marked chronic glomerulotubular lesions very similar to those produced by uranium. A slight degree of acquired immunity for HgCl2 can be demonstrated in regenerated epithelium and glomeruli. Glomerular injury, as evidenced by necrosis of epithelium, hemorrhages, and hyaline droplet degeneration, is less frequent than in the uranium kidney. A constant and striking phenomenon in the sublimate kidney is the envelopment of necrotic cells by regenerating epithelium. In the rabbit, Ca deposition in casts is inconstant.