VACCINATION AND LOCAL ANAPHYLAXIS

Abstract

During the recent small-pox epidemic in Western Pennsylvania, and particularly in Pittsburgh, which through the effective administration of the Department of Health was quickly circumscribed and subdued, the Physicians of our vicinity had an unusual opportunity to observe large numbers of vaccinations. It has been estimated that in Pittsburgh about one-third of the population was vaccinated. The ordinary vaccination with cow-pox creates little interest in the mind of the practicing physician, and the results are not carefully observed. There is one phase of this topic, however, which is very interesting, and while mention of it is made in the recesses of the English literature, I think that it is not presuming too much to say that it is not generally recognized, and that its explanation is almost unknown. A patient is vaccinated and after a slight redness or perhaps a small raised papule lasting one to three days the entire