Oncolytic Effect of Egypt Virus on a Human Epidermoid Carcinoma Grown in X-Irradiated Rats

Abstract

Egypt 101 virus possesses oncolytic activity against a human epidermoid carcinoma grown either in vivo in X-irradiated weanling rats or in vitro in tissue cultures of the rat propagated human tumor. Neither the rat hosts nor the few normal rat stromal cells which grew out in the cultures appeared to be affected by the virus. Egypt 101 proliferated in but did not damage 2 other human tumors grown in irradiated rats. This rat-tissue culture method of testing the oncolytic activity of a virus for any particular tumor might be employed in estimating the possible value of virus therapy for each individual patient.