Granulocyte Reserve Following Radiation Therapy as Studied by the Response to a Bacterial Endotoxin
Open Access
- 1 March 1965
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 25 (3), 310-324
- https://doi.org/10.1182/blood.v25.3.310.310
Abstract
The granulocyte response to an intravenous injection of Pyrexal, a highly purified bacterial endotoxin was used as an assay of the marrow granulocyte reserve in patients who had received radiation therapy for various types of neoplasms. The response to the endotoxin was correlated with the amount of marrow irradiated. Only those patients with large volumes of marrow irradiated had abnormal responses to Pyrexal. No patient receiving radiation therapy to the head and neck, or thorax, or pelvis alone, regardless of dose, developed an abnormal response to Pyrexal. Early changes in the marrow granulocyte reserve were also studied in patients before, during and after radiation therapy.Keywords
This publication has 3 references indexed in Scilit:
- Effects of Local Irradiation (Co60 Teletherapy) on the Peripheral Blood and Bone MarrowBlood, 1963
- The Granulocyte Response to an Endotoxin (Pyrexal) as a Measure of Functional Marrow Reserve in Cancer ChemotherapyAnnals of Internal Medicine, 1962
- QUANTITATIVE STUDIES OF HUMAN LEUKOCYTIC AND FEBRILE RESPONSE TO SINGLE AND REPEATED DOSES OF PURIFIED BACTERIAL ENDOTOXIN*JCI Insight, 1962