The aging process is characterized by ptosis of the fatty compartments of the face, loss of subcutaneous volume, weakening of the supporting structures of the face. In this process movement may occur, atrophy of the deep pads and hypertrophy of different superficial fat pads, for unknown causes, leaving the nasolabial fat prominent [3,4]. Currently, facial fat reduction can be performed by liposuction only in the submental and cervical regions [7]. Other minimally invasive treatments such as subcutaneous mesotherapy with deoxycholic acid or sodium deoxycholate associated with other active ingredients are being studied in aesthetic medicine to allow treatment of other areas of the face [2,4,6]. The development of new techniques is promising, such as the subcision of adipose tissue, already used in cellulite, is believed to allow the migration of fat cells in facial compartments to other compartments with lower volume, inducing an increase in adipose tissue in deficient compartments, and increases the stimulation of collagen evidenced in the treatment of acne scars [1,5]. As well as, the lack of standardization of mesotherapy techniques “chemical lipolysis” to reduce fat compartments. This prospective experimental clinical study was performed with 5 female patients. Clinical evidence was sought for the reduction of nasolabial fat compartments with modeling of facial fat and increase of self-esteem of patients with standardization of a new technique called lipostructure. Anthropometric measurements of the treated compartments and satisfaction research questionnaires of these patients will be used, as well as post-procedure follow-up to demonstrate the main adverse effects of this technique. The results found point to a mean reduction of 2.03% in the nasolabial fat of the patients studied (p ≤ 0.05), demonstrating its efficacy. The patient evaluation form 30 days after the procedure showed that 80% of the patients were satisfied (40% well satisfied and 40% very satisfied), demonstrating its efficiency