Induction of c-fos and c-myc expression in T lymphocytes after treatment with recombinant interleukin 1-alpha.
- 1 December 1986
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 137 (11), 3649-3651
- https://doi.org/10.4049/jimmunol.137.11.3649
Abstract
Our data demonstrate that an early-acting differentiation/growth factor, such as IL 1, can induce the sequential expression of c-fos and c-myc in lymphocytes. Because such a wide variety of agents induces c-onc expression in lymphocytes, we conclude that the expression of these cellular proto-oncogenes represents a common pathway of response of lymphocytes to an exogenous stimulatory signal regardless of the nature of the factor and its receptor.This publication has 19 references indexed in Scilit:
- Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes.Proceedings of the National Academy of Sciences, 1984
- Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformationCell, 1984
- Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factorCell, 1983
- Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2.Proceedings of the National Academy of Sciences, 1983
- Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.Journal of Biological Chemistry, 1982
- T cell growth factor receptors. Quantitation, specificity, and biological relevanceThe Journal of Experimental Medicine, 1981
- Isolation of human NK cells by density gradient centrifugationJournal of Immunological Methods, 1980
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979
- An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesisProceedings of the National Academy of Sciences, 1978
- Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment processProceedings of the National Academy of Sciences, 1977