Bradykinin-like immunoreactive neuronal systems localized histochemically in rat brain.
- 1 March 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (3), 1489-1493
- https://doi.org/10.1073/pnas.76.3.1489
Abstract
Bradykinin-like immunoreactive structures were localized in rat brain by the indirect immunofluorescence method. Specificity of staining was demonstrated by: (i) the absence of fluorescence when preimmune serum was used, (ii) the disappearance of fluorescence when sera were preadsorbed with bradykinin, and (iii) the presence of identical staining with two different antisera. Immunoreactive neuronal cells are observed only in the hypothalamus, with especially dense clusters overlying the periventricular and dorsomedial nuclei. Fibers and varicose processes are observed in the periaqueductal gray matter, hypothalamus, perirhinal and cingulate cortices, the ventral portion of caudate-putamen, and the lateral septal area.This publication has 15 references indexed in Scilit:
- Effect of intracerebroventricular bradykinin, angiotensin II, and substance P on multiple fixed-interval fixed-ratio responding in rabbitsPsychopharmacology, 1978
- Neurotensin: immunohistochemical localization in rat central nervous system.Proceedings of the National Academy of Sciences, 1977
- On the mechanism of the hypertensive action of intraseptal bradykinin in the ratNeuropharmacology, 1976
- Topographic atlas of catecholamine and acetylcholinesterase‐containing neurons in the rat brain. II. Hindbrain (mesencephalon, rhombencephalon)Journal of Comparative Neurology, 1974
- Central mechanisms of the hypertensive action of intraventricular bradykinin in the unanaesthetized ratNeuropharmacology, 1974
- POSSIBLE PHYSIOLOGICAL AND PATHOLOGICAL ROLES OF THE KALLIKREIN‐KININ SYSTEMThe Medical Journal of Australia, 1972
- Antinociceptive action of intraventricular bradykininNeuropharmacology, 1971
- THE PRESENCE OF BRADYKININ-LIKE POLYPEPTIDES, KININ-RELEASING AND DESTROYING ACTIVITY IN BRAINThe Japanese Journal of Physiology, 1968
- ZETLER'S SATELLITE POLYPEPTIDES OF SUBSTANCE P IN SUBCELLULAR PARTICLES OF BOVINE PERIPHERAL NERVESThe Japanese Journal of Physiology, 1968
- ON A KININ-LIKE SUBSTANCE IN THE NERVOUS TISSUE EXTRACTS TREATED WITH TRYPSINThe Japanese Journal of Physiology, 1961