Principles and effects of microRNA-mediated post-transcriptional gene regulation
- 9 October 2006
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 25 (46), 6163-6169
- https://doi.org/10.1038/sj.onc.1209909
Abstract
MicroRNAs (miRNAs) are abundant regulatory RNAs involved in the regulation of many key biological processes. Recent advances in understanding the mechanism of RNA interference and miRNA-mediated mechanisms shed light on major principals of the formation of the regulatory complex and provide models to explain how these small regulatory RNA species interfere with gene expression and how they influence the translational status of the transcriptome.Keywords
This publication has 106 references indexed in Scilit:
- On the origin and functions of RNA-mediated silencing: from protists to manCurrent Genetics, 2006
- The role of PACT in the RNA silencing pathwayThe EMBO Journal, 2006
- Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated PathwaysCell, 2006
- Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR EvolutionCell, 2005
- TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencingEMBO Reports, 2005
- TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencingNature, 2005
- Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi proteinNature, 2005
- Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA TargetsCell, 2005
- Prediction of Mammalian MicroRNA TargetsCell, 2003
- The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexesNature Structural & Molecular Biology, 2003