Pre- and post-junctional supersensitivity: Differentiation by intraventricular infusions of norepinephrine and methoxamine
- 1 January 1976
- journal article
- conference paper
- Published by Springer Nature in Psychopharmacology
- Vol. 50 (2), 145-148
- https://doi.org/10.1007/bf00430483
Abstract
Intraventricular infusions of methoxamine, an adrenergic agonist that has a relatively low affinity for the presynaptic uptake mechanism, produces a significant dose-dependent increase in locomotor activity comparable to the increase elicited by infusion of equimolar doses of norepinephrine (NE). The behavioral responsiveness to infusion of both NE and methoxamine was more than doubled 3 weeks after pretreatment with 6-hydroxydopamine (6-OHDA). These results indicate that the increased responsiveness to NE induced by 6-OHDA is due to enhanced postsynaptic receptor sensitivity rather than to a loss of presynaptic uptake inactivation.This publication has 18 references indexed in Scilit:
- The cyclic AMP response to noradrenalin in young adult rat brain following post-natal injections of 6-hydroxydopamineCellular and Molecular Life Sciences, 1974
- Long-term administration of d-amphetamine: Progressive augmentation of motor activity and stereotypyPharmacology Biochemistry and Behavior, 1974
- Ventricular infusion of norepinephrine and amphetamine: Direct versus indirect actionPharmacology Biochemistry and Behavior, 1974
- Norepinephrine Uptake into Cerebral Cortical Synaptosomes after One Fight or Electroconvulsive ShockScience, 1974
- Differential effects of reserpine and alpha-methyl-p-tyrosine on norepinephrine and dopamine induced behavioral activityPsychopharmacology, 1973
- Effect of intraventricular infusion of dopamine and norepinephrine on motor activityPhysiology & Behavior, 1972
- Increased cyclic AMP response to norepinephrine in the rat brain following 6-hydroxydopamineNeuropharmacology, 1972
- Thyroid State: Effects on Pre-and Postsynaptic Central Noradrenergic MechanismsScience, 1972
- Time course of the effects of 6‐hydroxydopamine on catecholamine‐containing neurones in rat hypothalamus and striatumBritish Journal of Pharmacology, 1970
- Behavioral Activation of Rats during Intraventricular Infusion of NorepinephrineProceedings of the National Academy of Sciences, 1970