Heparin Neutralization of PGI 2 : Effects Upon Platelets
- 3 August 1979
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 205 (4405), 499-501
- https://doi.org/10.1126/science.377493
Abstract
Heparin neutralizes the inhibitory effect of prostacyclin (PGI2) on platelet aggregation. The PGI2-induced enhancement of platelet cyclic adenosine monophosphate levels is also inhibited. The mechanism appears to involve a direct interaction in which heparin neutralizes the inhibitory effects of PGI2 on platelet aggregation but, at the same time, does not lose its own anticoagulant activity. These findings may explain instances in which heparin infusions have been reported to produce hyperaggregation of platelets, thrombotic episodes, and thrombocytopenia in patients.Keywords
This publication has 12 references indexed in Scilit:
- Anti-platelet action of intravenous infusion of prostacyclin in manThrombosis Research, 1978
- Effects of prostacyclin (PGX) on cyclic AMP concentrations in human plateletsProstaglandins, 1977
- Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acidProstaglandins, 1977
- HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATIONThe Lancet, 1977
- The chemical structure of prostaglandin X (prostacyclin)Prostaglandins, 1976
- An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregationNature, 1976
- Disseminated Intravascular Coagulation During Heparin TherapyAnnals of Internal Medicine, 1974
- Heparin effects on plasma lysolecithin formation and platelet aggregationAtherosclerosis, 1973
- The Platelet Aggregating Effect of Eight Commercial HeparinsScandinavian Journal of Haematology, 1972
- Comparison of the effect of heparin and citrate on platelet aggregationJournal of Clinical Pathology, 1969