Phosphonate analog of 2'-deoxy-5-fluorouridylic acid
- 1 January 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (1), 109-111
- https://doi.org/10.1021/jm00187a024
Abstract
The phosphonate analogue (6) [1-(2,5,6-trideoxy-.beta.-D-ribo-hexofuranosyl-5-fluorouracil)-6''-phosphonic acid] of 2''-deoxy-5-fluorouridylic acid was prepared via a Pfitzner-Moffatt oxidation and Wittig reaction. This compound inhibited thymidylate synthetase from 3 sources [Lactobacillus casei, Escherichia coli and coliphage T2] and was cytotoxic to [human larynx carcinoma] HEp2 cells in culture.This publication has 3 references indexed in Scilit:
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