Influence of Biofilm Formation byGardnerella vaginalisand Other Anaerobes on Bacterial Vaginosis
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- 16 June 2015
- journal article
- review article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 212 (12), 1856-1861
- https://doi.org/10.1093/infdis/jiv338
Abstract
Bacterial vaginosis (BV) is the worldwide leading vaginal disorder in women of reproductive age. BV is characterized by the replacement of beneficial lactobacilli and the augmentation of anaerobic bacteria. Gardnerella vaginalis is a predominant bacterial species, however, BV is also associated with other numerous anaerobes, such as Atopobium vaginae, Mobiluncus mulieris, Prevotella bivia, Fusobacterium nucleatum and Peptoniphilus sp.. Currently, the role of G. vaginalis in the etiology of BV remains a matter of controversy. It is however known that, in BV patients, a biofilm is usually formed on the vaginal epithelium and G. vaginalis is typically the predominant species. So, the current paradigm is that the establishment of a biofilm plays a key role in the pathogenesis of BV. This review provides background on the influence of biofilm formation by G. vaginalis and other anaerobes in the polymicrobial etiology of BV, through its initial adhesion until biofilm formation and discusses the commensal and synergic interactions established between them to understand the phenotypic shift of G. vaginalis' biofilms into BV establishment.Keywords
This publication has 48 references indexed in Scilit:
- Interactions between Lactobacillus crispatus and Bacterial Vaginosis (BV)-Associated Bacterial Species in Initial Attachment and Biofilm FormationInternational Journal of Molecular Sciences, 2013
- Fluorescence in situ Hybridization method using Peptide Nucleic Acid probes for rapid detection of Lactobacillus and Gardnerella spp.BMC Microbiology, 2013
- In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxideBMC Infectious Diseases, 2011
- The epidemiology of bacterial vaginosis in relation to sexual behaviourBMC Infectious Diseases, 2010
- Analysis of adherence, biofilm formation and cytotoxicity suggests a greater virulence potential of Gardnerella vaginalis relative to other bacterial-vaginosis-associated anaerobesMicrobiology, 2010
- Adaptation of Hansenula polymorpha to methanol: a transcriptome analysisBMC Genomics, 2010
- Mutualistic Biofilm Communities Develop with Porphyromonas gingivalis and Initial, Early, and Late Colonizers of EnamelJournal of Bacteriology, 2009
- Diversity of Human Vaginal Bacterial Communities and Associations with Clinically Defined Bacterial VaginosisApplied and Environmental Microbiology, 2008
- Molecular Quantification ofGardnerella vaginalisandAtopobium vaginaeLoads to Predict Bacterial VaginosisClinical Infectious Diseases, 2008
- Endometrioma Complicated by Tubo-Ovarian Abscess in a Woman With Bacterial VaginosisInfectious Diseases in Obstetrics and Gynecology, 2006