Molecular evolution of receptors for eicosanoids
- 7 March 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 361 (1), 17-21
- https://doi.org/10.1016/0014-5793(95)00129-w
Abstract
The amino acid sequences of the receptors for various prostaglandins, thromboxane and lipoxin, which belong to the rhodopsin family, were aligned, and a phylogenetic tree was constructed to infer the evolutionary history of the arachidonic acid cascade. The obtained tree suggested that the origin of the cyclooxygenase pathway was different from that of the lipoxygenase pathway. The receptors involved in the cyclooxygenase pathway constructed an independent cluster, but the lipoxin A4 receptor, which is involved in the lipoxygenase pathway, belonged to the cluster of peptide receptors. The primitive form of the cyclooxygenase pathway had been a signal transduction system composed of prostaglandin E2 and its receptor associated with cAMP metabolism.Keywords
This publication has 40 references indexed in Scilit:
- Molecular Cloning and Expression of Rat Prostaglandin E Receptor EP2 SubtypeBiochemical and Biophysical Research Communications, 1994
- Two Isoforms of the Rat Kidney EP3 Receptor Derived by Alternative RNA Splicing: Intrarenal Expression Co-localizationBiochemical and Biophysical Research Communications, 1994
- Cloning and Expression of the EP3-Subtype of Human Receptors for Prostaglandin E2Biochemical and Biophysical Research Communications, 1994
- Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1a receptorBiochemical and Biophysical Research Communications, 1992
- Mouse thromboxane A2 receptor: cDNA cloning, expression and Northern blot analysisBiochemical and Biophysical Research Communications, 1992
- cDNA Sequence and heterologous expression of the human neurokinin-3 receptorBiochemical and Biophysical Research Communications, 1992
- Cloning and characterization of cDNA encoding human a-type endothelin receptorBiochemical and Biophysical Research Communications, 1991
- Characterization of a human cDNA that encodes a functional receptor for platelet activating factorBiochemical and Biophysical Research Communications, 1991
- Molecular cloning, structural characterization and functional expression of the human substance P receptorBiochemical and Biophysical Research Communications, 1991
- Tests for comparing related amino-acid sequences. Cytochrome c and cytochrome c551Journal of Molecular Biology, 1971