Reversal of Methotrexate Toxicity in Mice by 5-Methyltetrahydrofolic Acid
Open Access
- 1 September 1970
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 24 (3), 603-609
- https://doi.org/10.1038/bjc.1970.73
Abstract
1. Mice have been compeletly protected against the lethal effects of repeated injections of methotrexate by 5-methyltetrahydrofolic acid. Methotrexate-resistant cells probably owe their resistance to their high content of this substance. 2. Daily small doses were much more effective than fewer but larger doses. 3. The reduced efficiency found in counteracting high dosages of methotrexate may be due to interference with folate transport across cell walls. 4. 5-Methyltetrahydrofolic acid and citrovorum factor did not differ greatly in their ability to inhibit methotre toxicity. It is suggested that the pharmaceutical effects of citrovorum factor are due to its conversion to 5-methyltetrahydrofolic acid.Keywords
This publication has 5 references indexed in Scilit:
- Characteristics of folic acid transport in the L1210 leukemia cellBiochimica et Biophysica Acta (BBA) - Biomembranes, 1969
- Transport energetics of the folic acid analogue, methotrexate, in L1210 leukemia cells. Enhanced accumulation by metabolic inhibitors.1969
- Cell killing studies on the mode of action of methotrexate on L-cells in vitro.1969
- [A new combination of methotrexate and folinic acid for cancer treatment (acute leukemia and solid tumors)].1969
- STUDIES ON UNBALANCED GROWTH IN TISSUE CULTURE .1. INDUCTION AND CONSEQUENCES OF THYMIDINE DEFICIENCY1960