Enantioselective Synthesis of 3,3-Disubstituted Oxindoles through Pd-Catalyzed Cyanoamidation
- 27 June 2008
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (15), 3303-3306
- https://doi.org/10.1021/ol801168j
Abstract
The first enantioselective cyanoamidation of olefins provides quick access to a variety of 3,3-disubstituted oxindoles. The combination of Pd(dba)2, an optically active phosphoramidite, and N, N-dimethylpropylene urea (DMPU) in decalin were found to be the best conditions.Keywords
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