Respect Thy Neighbor!
- 6 February 2004
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 303 (5659), 775-777
- https://doi.org/10.1126/science.1094412
Abstract
The tissue microenvironment surrounding tumor cells may not be just a passive bystander during tumorigenesis. In their Perspective, Radisky and Bissell discuss new work showing that mice with stromal cells unable to respond to the cytokine TGF-rapidly develop epithelial tumors ( Bhowmick et al.). The Perspective authors explore the implications of the finding that stromal cells are a protective influence on epithelial cells, preventing them from becoming tumorigenic.Keywords
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