Real‐Time Monitoring of Electrically Stimulated Norepinephrine Release in Rat Thalamus: II. Modeling of Release and Reuptake Characteristics of Stimulated Norepinephrine Overflow
Open Access
- 1 February 1993
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 60 (2), 449-453
- https://doi.org/10.1111/j.1471-4159.1993.tb03171.x
Abstract
As in the preceding study, electrical stimulation was used to effect release overflow of norepinephrine in the rat thalamus. Using a weak electrochemical pretreatment of a carbon fiber electrode, it was possible to "tune in" the electrochemical response signal for norepinephrine without metabolite interference. This reasonably selective signal was then used to study the degradation of norepinephrine release ability caused by prolonged stimulation. Further, the signals were modeled by the method used successfully for stimulated dopamine overflow, providing hitherto unavailable information on the temporal and spatial characteristics of norepinephrine release overflow. Pertinent comparisons between the release characteristics of the dopamine and norepinephrine systems show that the half-life for norepinephrine in the extracellular fluid space is approximately 1 s in thalamus compared with 33 ms for dopamine in caudate.Keywords
This publication has 11 references indexed in Scilit:
- Real‐Time Monitoring of Electrically Stimulated Norepinephrine Release in Rat Thalamus: I. Resolution of Transmitter and Metabolite Signal ComponentsJournal of Neurochemistry, 1993
- Control of dopamine extracellular concentration in rat striatum by impulse flow and uptakeBrain Research Reviews, 1990
- Nafion‐coated carbon fiber electrodes for neurochemical studies in brain tissueElectroanalysis, 1990
- Effects of D‐2 Antagonists on Frequency‐Dependent Stimulated Dopamine Overflow in Nucleus Accumbens and Caudate‐PutamenJournal of Neurochemistry, 1989
- Heterogeneity of stimulated dopamine overflow within rat striatum as observed with in vivo voltammetryBrain Research, 1989
- Differentiation of Dopamine Overflow and Uptake Processes in the Extracellular Fluid of the Rat Caudate Nucleus with Fast‐Scan In Vivo VoltammetryJournal of Neurochemistry, 1988
- Real-time characterization of dopamine overflow and uptake in the rat striatumNeuroscience, 1988
- Diffusional distortion in the monitoring of dynamic eventsAnalytical Chemistry, 1988
- Mechanisms contributing to the recovery of striatal releasable dopamine following MFB stimulationBrain Research, 1987
- In vivo voltammetric characterization of low affinity striatal dopamine uptake: Drug inhibition profile and relation to dopaminergic innervation densityBrain Research, 1986