REACTIVITY OF XENOGENEIC ANTIHUMAN la ANTISERA WITH THE I-C SUBREGION OF THE MURINE MAJOR HISTOCOMPATIBILITY COMPLEX

Abstract

Several rabbit xenoantisera raised against human serum Ia antigens detected murine lymphocyte antigens. The murine system detected was polymorphic and expressed on B cells and not T cells. Serological analysis of recombinant H-2 strains demonstrated that 2 of the antisera recognized products of the I-Cd subregion, and 1 antiserum recognized products of the I-Cb subregion, clearly establishing the I-C subregion in these 2 haplotypes. As the I-Cd subregion is classically described by the Ia.6 specificity present on T cells and xenoantisera detect a product on B cells, the I-C region, like I-A and I-J, apparently complexes and contains genes coding for specificities on T cells or B cells.