Effect of Drugs on Cx-Protein Responses in the Rabbit.
- 1 December 1960
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 105 (3), 510-514
- https://doi.org/10.3181/00379727-105-26160
Abstract
Methyl prednisolone and fluorometholone prevented the appearance of Cx-reactive protein (CxRP) in rabbit serum following subcutaneous injection of mineral oil-Aquaphor emulsion. Fluorometholone was unable to block CxRP responses to 250 r whole body irradiation or to intravenous injection of Thorotrast or Varidase. It did block CxRP responses to intravenous injection of post irradiation seromucoid or tobacco mosaic virus and the intravascular formation of antigen-antibody complexes. Under appropriate time dose conditions fluorometholone inhibited both antibody production and CxRP appearance while under other time dose conditions CxRP appearance was prevented without alteration of antibody production.Keywords
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