TOWARD A REALISTIC MODEL OF MUTATIONS AFFECTING FITNESS
Open Access
- 1 March 2003
- Vol. 57 (3), 683-685
- https://doi.org/10.1111/j.0014-3820.2003.tb01561.x
Abstract
Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.Keywords
This publication has 15 references indexed in Scilit:
- Quantifying the Slightly Deleterious Mutation Model of Molecular EvolutionMolecular Biology and Evolution, 2002
- Estimation of spontaneous genome-wide mutation rate parameters: whither beneficial mutations?Heredity, 2000
- Properties of spontaneous mutations affecting quantitative traitsGenetics Research, 1999
- Mutational Contributions to Genetic Variance-Covariance Matrices: An Experimental Approach Using Induced Mutations in Arabidopsis thalianaEvolution, 1999
- Perspective: Spontaneous Deleterious MutationEvolution, 1999
- New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogasterProceedings of the National Academy of Sciences, 1999
- Test of synergistic interactions among deleterious mutations in bacteriaNature, 1997
- The Rate and Effects Distribution of Viability Mutation in Drosophila: Minimum Distance EstimationEvolution, 1997
- Genomic mutation rates for lifetime reproductive output and lifespan in Caenorhabditis elegansProceedings of the National Academy of Sciences, 1997
- Estimate of the genomic mutation rate deleterious to overall fitness in E. collNature, 1996