Anatomic Evidence for Spontaneous Closure of Ventricular Septal Defect

Abstract
Pathological evidence for spontaneous closure of ventricular septal defect in seven adults has been presented. These cases were observed among 1,605 necropsies (an incidence of about 1 per 225 necropsies). In two of the cases, the ventricular septal defect was closed by an adherent tricuspid valve, possibly the result of bacterial endocarditis. In the remaining five cases a muscular ventricular septal defect was closed by a fibrous membrane.