Reprogramming metastatic tumour cells with embryonic microenvironments
- 1 April 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 7 (4), 246-255
- https://doi.org/10.1038/nrc2108
Abstract
Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration.Keywords
This publication has 90 references indexed in Scilit:
- The cancer stem cell hypothesis: a work in progressLaboratory Investigation, 2006
- Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem CellsCancer Research, 2006
- Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressivenessNature Medicine, 2006
- Normal Stem Cells and Cancer Stem Cells: The Niche MattersCancer Research, 2006
- A Tumorigenic Subpopulation with Stem Cell Properties in MelanomasCancer Research, 2005
- Gastric Cancer Originating from Bone Marrow-Derived CellsScience, 2004
- Stem cell origin of cancer and differentiation therapyCritical Reviews in Oncology/Hematology, 2004
- Prospective identification of tumorigenic breast cancer cellsProceedings of the National Academy of Sciences, 2003
- Human embryonic genes re-expressed in cancer cellsOncogene, 2001
- A cell initiating human acute myeloid leukaemia after transplantation into SCID miceNature, 1994