Comparison of High and Low Dosage Levels of131I in the Treatment of Thyrotoxicosis

Abstract

THE appearance of permanent hypothyroidism several years after treatment of thyrotoxicosis with radioactive iodine (¹³¹I) was pointed out in the review of Chapman and Maloof¹ in 1955. Its steadily increasing occurrence during the passage of time was reported in 1961 by Beling and Einhorn.² The data of Dunn and Chapman³ show that radioactive iodine hypothyroidism occurs in 25 per cent of patients two years after ¹³¹I, the rate steadily increasing to 40 per cent after ten years.³ More recently, Nofal, Beierwaltes and Patno⁴ reported permanent hypothyroidism in 45 per cent after two years, the figure reaching about 70 per . . .