Relationship of alterations in splenic clearance function and microcirculation to host defense in acute rodent malaria.
Open Access
- 1 May 1981
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 67 (5), 1400-1404
- https://doi.org/10.1172/jci110168
Abstract
During the course of Plasmodium berghei malaria in the rat, splenic clearance of damaged uninfected erythrocytes (heated or Heinz body-containing) underwent changes strikingly similar to those of infected erythrocytes. Splenic trapping of abnormal erythrocytes was impaired during the period of rising parasitemia but became supernormal just before the onset of resolution of the acute infection. These changes could be related to the development of splenomegaly and alterations in splenic cordal microcirculation during infection. The relative distribution of flow through the cords was decreased during rising parasitemia and was restored before the onset of resolution. Together, our observations support the hypothesis that altered rheologic properties of infected erythrocytes are a major determinant of their removal by the spleen. These data suggest that the alterations in splenic microcirculation that occur during malaria may have important implications for host defense.Keywords
This publication has 10 references indexed in Scilit:
- Resolution of Acute Malaria (Plasmodium Berghei in the Rat): Reversibility and Spleen DependenceThe American Journal of Tropical Medicine and Hygiene, 1980
- Mechanisms of Action of Hyperimmune Serum in Mediating Protective Immunity to Rodent Malaria (Plasmodium Berghei)The Journal of Immunology, 1979
- Intravascular Clearance of Parasitized Erythrocytes in Rodent MalariaJCI Insight, 1979
- Microcirculation of the Spleen: An Open or Closed Circulation?Science, 1978
- Specific and Non-Specific Immunity to HaemoprotozoaThe American Journal of Tropical Medicine and Hygiene, 1977
- The Role of the Sinus Wall in the Passage of Erythrocytes Through the SpleenBlood, 1973
- An Ultrastructural Study of the Red Pulp of the Spleen in MalariaBlood, 1973
- Alteration in the rheologic properties of plasmodium knowlesi-infected red cells. A possible mechanism for capillary obstructionJCI Insight, 1971
- Anatomical hazards to the passage of erythrocytes through the spleen.1970
- The Circulation of the Fetus in UteroCirculation Research, 1967