Depressions in the Activity of Liver Catalase in Mice Injected with Homogenates of Normal Mouse Spleen2

Abstract

The liver catalase activity in strain C57BR/a mice, injected with homogenized spleen from strain A mice, is depressed to an extent nearly equivalent to the depression in activity in those C57BR/a mice injected with a comparable amount of lyophilized Sarcoma I, a tumor indigenous to the A strain. The extent to which depressions in liver catalase occur in mice of 7 strains, injected with homogenized spleen from mice of 8 strains, is qualitatively but not quantitatively related to the dosage of spleen injected. A hypothesis to explain the general phenomenon of liver catalase activity depressions is presented. The normal level of liver catalase activity in male mice is significantly lower than in females of 2 inbred strains; significantly higher than in females of one strain; and not significantly different from the liver catalase activities in females of 3 strains.