Hormone Serum Levels and Hormone Receptor Contents of Endometria in Women with Normal Menstrual Cycles and Patients Bearing Endometrial Carcinoma
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 10 (2-3), 71-80
- https://doi.org/10.1159/000299920
Abstract
Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (HPRL), 17Β-estradiol (E2) and progesterone (P) were estimated in 46 subjects with normal menstrual cycles in whom hysterectomies were performed. Estrogen (ER) and progesterone receptor (PgR) levels in endometrial samples of these patients were estimated, and histological dating of the cycle day was carried out. Similarly, hormone serum levels and ER as well as PgR were estimated in 17 patients with endometrial carcinoma. No correlation between LH, FSH, HPRL and ER as well as PgR was noted in the normal subjects. Correlation between P and ER was observed in this group. Parallel variations between E2 and PgR were recorded in the normal females. In the carcinoma group no correlations between hormone serum levels and receptor contents were found, but ER and PgR correlated with each other. Receptor levels were highest in the well-differentiated group of endometrial carcinoma. The present experiments provide a rationale for progestagen therapy of carcinoma of the endometrium.Keywords
This publication has 8 references indexed in Scilit:
- Plasma oestradiol and progesterone levels in women with varying degrees of risk of breast cancerEuropean Journal of Cancer (1965), 1978
- The effects of oestrogens and progestogens on the postmenopausal endometriumMaturitas, 1978
- Alterations in Human Endometrial Protein Synthesis During the Menstrual Cycle and in Progestone-Stimulated Organ Culture**Supported by a Basil O’Connor Starter research grant from The National Foundation-March of Dimes.Fertility and Sterility, 1978
- VARIATIONS IN UTERINE CYTOSOLIC OESTROGEN AND PROGESTERONE RECEPTOR LEVELS DURING THE RAT OESTROUS CYCLEActa Endocrinologica, 1977
- Progesterone-regulated changes in transcriptional events in rabbit uterusBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977
- Estrogen and Endometrial CarcinomaNew England Journal of Medicine, 1977
- Suppression of the Estradiol Receptor System by Progesterone in the Oviduct and Uterus of the Cat12Endocrinology, 1976
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951