A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene
Open Access
- 3 August 2011
- journal article
- research article
- Published by Springer Nature in European Journal of Human Genetics
- Vol. 20 (1), 84-90
- https://doi.org/10.1038/ejhg.2011.148
Abstract
Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case–control sample. However, analyses of a larger independent Danish case–control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.Keywords
This publication has 43 references indexed in Scilit:
- Deletion 17q12 Is a Recurrent Copy Number Variant that Confers High Risk of Autism and SchizophreniaAmerican Journal of Human Genetics, 2010
- Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysisThe Lancet, 2010
- The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear BehaviorCell, 2009
- Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alphaMolecular Psychiatry, 2009
- Isolated populations and complex disease gene identificationGenome Biology, 2008
- PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics, 2007
- The Epidemiology of Panic Attacks, Panic Disorder, and Agoraphobia in the National Comorbidity Survey ReplicationArchives of General Psychiatry, 2006
- Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 2004
- The origin of the isolated population of the Faroe Islands investigated using Y chromosomal markersHuman Genetics, 2004
- A Review and Meta-Analysis of the Genetic Epidemiology of Anxiety DisordersAmerican Journal of Psychiatry, 2001