BL-S 640, a Cephalosporin with a Broad Spectrum of Antibacterial Activity: Properties In Vitro
- 1 March 1975
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 7 (3), 298-305
- https://doi.org/10.1128/aac.7.3.298
Abstract
BL-S 640 was evaluated in vitro by comparison with cephalothin, cephaloridine, cefazolin, and cephalexin. The new compound was more active than the control cephalosporins against most major gram-negative and some gram-positive species. Moreover, its antibacterial spectrum included strains of Enterobacter, Proteus morganii, P. rettgeri , and Providencia stuartii , species generally resistant to the other cephalosporins. BL-S 640 was an effective bactericidal agent for strains of various species of Enterobacteriaceae . In human plasma, the compound was 58% protein bound.Keywords
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