It has been stated that cases of acne constitute about 8.5 per cent of all cases seen in dermatologic practice (Darier and Pollitzer1). The thought of the disease is a nightmare to young persons of both sexes and to their parents. A brief review of the etiologic factors as given in the textbooks of three generations of writers is therefore of interest. Jackson,2 in 1892, stated that youth is the greatest predisposing factor in acne; hereditary disorders of the digestive and sex organs were also mentioned as an influence in the production of symptoms. He considered that the development of sex organs and disturbances in menstruation affect the digestive mechanism and that in most cases acne is amenable to treatment through diet and regulation of the digestive functions. Stelwagon,3 in 1921, in summarizing the current views, touched on the theory that acne is due to parasitic invasion,