ENANTIOSELECTIVE ADDITION OF ACETYLENE TO ALDEHYDE. PREPARATION OF OPTICALLY ACTIVE ALKYNYL ALCOHOLS
- 5 May 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 8 (5), 447-448
- https://doi.org/10.1246/cl.1979.447
Abstract
Enantioselective addition of acetylene to aldehyde was investigated by the use of (2S, 2′S)-2-hydroxymethyl-1-[(1-methylpyrrolidin-2-yl)methyl]pyrrolidine as a chiral ligand. The addition of lithium trimethylsilylacetylide to benzaldehyde afforded the corresponding alkynyl alcohol in 92% optical yield.Keywords
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