DOSE REQUIREMENTS OF PROPOFOL BY INFUSION DURING NITROUS OXIDE ANAESTHESIA IN MAN
Open Access
- 1 March 1987
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 59 (3), 283-287
- https://doi.org/10.1093/bja/59.3.283
Abstract
The infusion rate of propofol required to supplement 67% nitrous oxide in oxygen to maintain surgical anaesthesia was determined in 72 patients premedicated with lorazepam. Following an induction dose of propofol 2 mg kg−1, groups of eight patients received an infusion of propofol varying from 60 to 200 μg kg−1. Probit analysis was used to determine the ED50 (130 μg kgminus;1 min−1; 95% confidence limits: 106–167 μg kg−1 min−1) and ED95 (348 μg kg−1 min−1; 95% confidence limits: 233–1296 μg kg−1 min−1;) for propofol infusion. Whole blood propofol concentrations at the time of surgical incision correlated strongly with the infusion rate, giving an EC50 value of 2.5 μg ml −1, and an EC95 value of 5.92 μg ml−1. There was no significant correlation between the rate of infusion of propofol, or the total propofol dose, and the times to response to command, or to recall of birthdate.This publication has 2 references indexed in Scilit:
- DOSE REQUIREMENTS OF PROPOFOL BY INFUSION DURING NITROUS OXIDE ANAESTHESIA IN MANBritish Journal of Anaesthesia, 1986
- A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS1949