Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions
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Open Access
- 10 June 2009
- journal article
- Published by Springer Nature in Journal of Cheminformatics
- Vol. 1 (1), 8
- https://doi.org/10.1186/1758-2946-1-8
Abstract
A method to estimate ease of synthesis (synthetic accessibility) of drug-like molecules is needed in many areas of the drug discovery process. The development and validation of such a method that is able to characterize molecule synthetic accessibility as a score between 1 (easy to make) and 10 (very difficult to make) is described in this article.Keywords
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