ANTI-TUMOR EFFECT OF POLYSACCHARIDE TC-13 ON ALLOGENEIC AND SYNGENEIC TUMORS IN MICE

Abstract

The antitumor activity of TC-13, a protein-bound polysaccharide extracted from a rare actinomycetes [Microellobosporia grisea] was tested on allogeneic and syngeneic tumors in mice. In the allogeneic [mouse] Ehrlich carcinoma system, TC-13 showed antitumor activity over a broad optimal dose range, when administered by various routes, e.g., i.p., i.v., s.c., i.t. (intratumorally) or per os, even when given before tumor inoculation. TC-13 showed synergistic antitumor effects in combination with other immunomodulators, e.g., lipopolysaccharide, lentinan and picibanil. It showed antitumor activity against the syngeneic [mouse] tumors MM46 mammary carcinoma and MCS-8 fibrosarcoma and Meth A fibrosarcoma.