The Rat Growth Factors of the Filtrate Fraction of Liver Extracts
- 1 September 1939
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 18 (3), 265-276
- https://doi.org/10.1093/jn/18.3.265
Abstract
Albino rats grew only slowly when given a basal diet essentially free from B-vitamins, but supplemented by adequate amounts of pure thiamin and riboflavin and by fuller's earth adsorbate from liver extracts. The growth-promoting substances of the fuller's earth filtrate could be concentrated by extraction with amyl alcohol, adsorption and elution from charcoal and by continuous ether extraction of the acid aqueous solution. The activity of the ether extract could be concentrated further by fractionation of the brucine and calcium salts. It is suggested that pantothenic acid is responsible for part of the growth-promoting activity of liver extracts.Keywords
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