Erythroid Progenitors Circulating in the Blood of Adult Individuals Produce Fetal Hemoglobin in Culture
- 24 March 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4335), 1349-1350
- https://doi.org/10.1126/science.628844
Abstract
Erythroid colonies, raised from erythroid stem cells circulating in the peripheral blood of normal adult individuals, synthesize considerable amounts of fetal hemoglobin. In cultures from persons with sickling disorders, amounts of hemoglobin F that are known to inhibit sickling in vivo are produced. The results provide evidence that primitive erythroid progenitors are able to express the hemoglobin F production program and that cultures of mononuclear cells of the adult blood can be used to investigate the mechanisms involved in regulation of gamma-globin gene switching.This publication has 4 references indexed in Scilit:
- Hemoglobin F synthesis in vitro: evidence for control at the level of primitive erythroid stem cells.Proceedings of the National Academy of Sciences, 1977
- Characterization of an erythroid precursor cell of high proliferative capacity in normal human peripheral blood.Proceedings of the National Academy of Sciences, 1977
- Stimulation of fetal hemoglobin synthesis in bone marrow cultures from adult individuals.Proceedings of the National Academy of Sciences, 1976
- Erythropoietic Colonies in Cultures of Human MarrowBlood, 1974