THE MODE AND SITE OF THE RENAL ACTION OF PARATHYROID EXTRACT IN THE DOG

Abstract

When 20 U.S.P. units per kg of parathyroid extract were injected intravenously into dogs with unilateral distal tubular nephrosis, the phosphate excretion from the normal kidney increased significantly, but there was no change in the amount of phosphate excreted by the nephrotic kidney. In dogs with unilateral nephrosis affecting the first third or the last two thirds of the proximal tubules, parathyroid extract produced a similar increase in phosphate excretion by the normal and the nephrotic kidneys. It is concluded that the site of renal action of parathyroid extract is in the distal tubule and that its mode of action is to stimulate active excretion of phosphate.