Metabolism of nephrotoxiccis‐andtrans‐decalin in fischer‐344 rats

Abstract

The cis‐ and trans‐decalin stereoisomers have found many uses as solvents and fuel components. The metabolism of the decalin isomers in male and female Fischer‐344 rats and the effects of the decalins on renal damage were evaluated. Only male rats had kidney damage. Metabolism of cis‐decalin yielded cis,trans‐7‐decalol and cis, cis‐2‐decalol in the urine of both sexes, with the male also producing cis,cis‐1‐decalol. The urinary metabolites of trans‐decalin included trans, cis‐2‐decalol in both male and female rats and trans,trans‐7‐decalol in males. Extracts of kidney homogenates from male rats, but not from females, dosed with cis‐ and trans‐decalin yielded cis‐2‐deca‐lone and trans‐2‐decalone, respectively. A single male rat treated with trans‐decalin produced no 2‐decalone in the kidney extract and also showed no renal damage.