Molecular basis for modulated regulation of gene expression in the arginine regulon ofEscherichia coliK-12
Open Access
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 11 (15), 5007-5019
- https://doi.org/10.1093/nar/11.15.5007
Abstract
We compare the nucleotide sequences of the regulatory regions of five genes or groups of genes of the arginine regulon of Escherichia coli K-12 : argF, argI, argR, the bipolar argECBH operon and the carAB operon. All these regions harbour one or two copies of a conserved 18 bp sequence which appears to constitute the basic arginine operator sequence (ARG box) . We discuss the influence of ARG box copy number, degree of dyad symmetry, base composition, and position relative to the cognate promoter site on the derepression-repression ratios of the genes of the regulon. A novel hypothesis, based on structural considerations, is also put forward to account for the absence ot attenuation control.Keywords
This publication has 30 references indexed in Scilit:
- N-Acetylglutamate synthase of Escherichia coli regulation of synthesis and activity by arginine.Journal of Biological Chemistry, 1975
- Parameters of gene expression in the bipolar argECBH operon of E. coli K12Molecular Genetics and Genomics, 1975
- Mutations affecting uridine monophosphate pyrophosphorylase or the argR gene in Escherichia coliMolecular Genetics and Genomics, 1972
- Studies on the mechanism of repression of arginine biosynthesis in Escherichia coli: IV. Further studies on the role of arginine transfer RNA repression of the enzymes of arginine biosynthesisJournal of Molecular Biology, 1971
- Reversible Dissociation of Carbamyl Phosphate Synthetase into a Regulated Synthesis Subunit and a Subunit Required for Glutamine UtilizationProceedings of the National Academy of Sciences, 1971
- Regulation at the level of translation in the arginine pathway of Escherichia coli K12Journal of Molecular Biology, 1970
- A mechanism for repressor actionJournal of Molecular Biology, 1969
- On the functional organization of the arg ECBH cluster of genes in Escherichia coli K-12Molecular Genetics and Genomics, 1969
- Control of the biosynthesis of carbamoyl phosphate in Escherichia coliJournal of Molecular Biology, 1965
- Coordination of enzyme synthesis in the arginine pathway of Escherichia coli K-12Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1965