Long‐term therapy of paget's disease of bone with ehdp
- 1 October 1980
- journal article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 23 (10), 1177-1184
- https://doi.org/10.1002/art.1780231016
Abstract
Forty patients with Paget's disease of bone were treated with intermittent courses of the diphosphonate, EHDP. Seven individuals had prolonged remissions after their initial course of therapy, nineteen responded to retreatment with 5 mg/kg of EHDP for 6 months of each year, while 14 patients required cycles of 20 mg/kg for 1 month of every 4. Improvement was indicated by alleviation of symptoms and reduction in serum alkaline phosphatase and urinary hydroxyproline. Data suggesting a possible role for parathyroid hormone in the expression of Paget's disease are also discussed.Keywords
This publication has 16 references indexed in Scilit:
- Paget's disease of bone and hyperparathyroidism: Coincidence or causal relationship?Calcified Tissue International, 1978
- Response of 1α,25-Dihydroxyvitamin D3to Hypocalcemia in Human SubjectsNew England Journal of Medicine, 1978
- Paget's disease of bone—a clinical and genetic studyPublished by Oxford University Press (OUP) ,1977
- Treatment of Paget disease of bone (osteitis deformans). Results of a one-year study with sodium etidronatePublished by American Medical Association (AMA) ,1974
- DIPHOSPHONATES IN PAGET'S DISEASEThe Lancet, 1974
- Diphosphonate Treatment of Paget's Disease of BoneHormone and Metabolic Research, 1974
- Radiological evidence of a dose-related response to long-term treatment of Paget's disease with human calcitoninThe British Journal of Radiology, 1974
- PARATHYROID FUNCTION IN PATIENTS WITH PAGET'S DISEASE TREATED WITH SALMON CALCITONINClinical Endocrinology, 1973
- DIPHOSPHONATES AND PAGET'S DISEASE OF BONEThe Lancet, 1971
- Modifications of a specific assay for hydroxyproline in urineAnalytical Biochemistry, 1967