An Escherichia coli Reference Collection Group B2- and Uropathogen-Associated Polymorphism in the rpoS-mutS Region of the E. coli Chromosome

Abstract

Chromosomal DNAs of enterohemorrhagic, uropathogenic, and laboratory attenuated Escherichia coli strains differ in the rpoS-mutS region. Many uropathogens lack a deletion and an insertion characteristic of enterohemorrhagic strains. At the same chromosomal position, they harbor a 2.1-kb insertion of unknown origin with a base composition suggestive of horizontal gene transfer. Unlike virulence determinants associated with urinary tract infection and/or neonatal meningitis ( pap or prs , sfa , kps , and hly ), the 2.1-kb insertion is shared by all group B2 strains of the E. coli Reference Collection.