Cold exposure potentiates the effect of insulin on in vivo glucose uptake
- 1 August 1987
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Endocrinology and Metabolism
- Vol. 253 (2), E179-E186
- https://doi.org/10.1152/ajpendo.1987.253.2.e179
Abstract
The effects of cold exposure (48 h at 4 degrees C) and insulin injection (0.5 U/kg iv) on the rates of net 2-[3H]deoxyglucose uptake (Ki) in peripheral tissues were investigated in warm-acclimated rats (25 degrees C). Cold exposure and insulin treatment independently increased Ki values in skeletal muscles (soleus, extensor digitorum longus, and vastus lateralis), heart, white adipose tissue (subcutaneous, gonadal, and retroperitoneal), and brown adipose tissue (P less than 0.01). The effects of cold exposure were particularly evident in brown adipose tissue where the Ki increased greater than 100 times. When the two treatments were combined (insulin injection in cold-exposed rats), it was found that cold exposure synergistically enhanced the maximal insulin responses for glucose uptake in brown adipose tissue, all white adipose tissue depots, and skeletal muscles investigated. The results indicate that cold exposure induces an "insulin-like" effect on Ki that does not appear to be specifically associated with shivering thermogenesis in skeletal muscles, because that effect was observed in all insulin-sensitive tissues. The data also demonstrate that cold exposure significantly potentiates the maximal insulin responses for glucose uptake in the same tissues. This potentialization may result from an enhanced responsiveness of peripheral tissues to insulin, possibly occurring at metabolic steps lying beyond the insulin receptor and an increased tissue blood flow augmenting glucose and insulin availability and thereby amplifying glucose uptake.This publication has 26 references indexed in Scilit:
- Intensive Exercise Training Does not Improve Intravenous Glucose Tolerance in Severely Diabetic RatsHormone and Metabolic Research, 1986
- Effect of physical training on glucose transporters in fat cell fractionsBiochimica et Biophysica Acta (BBA) - General Subjects, 1985
- Increased insulin sensitivity in soleus muscle from cold-exposed rats: reversal by an adenosine-receptor agonistFEBS Letters, 1984
- The regulation of fatty acid synthesis in brown adipose tissue by insulinProgress in Lipid Research, 1982
- Synergistic interaction between exercise and insulin on peripheral glucose uptake.JCI Insight, 1981
- Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.JCI Insight, 1981
- Effect of physical training on glucose tolerance and on glucose metabolism of skeletal muscle in anaesthetized normal ratsDiabetologia, 1979
- Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesisCanadian Journal of Physiology and Pharmacology, 1979
- THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT1Journal of Neurochemistry, 1977
- HINDLIMB MUSCLE FIBER POPULATIONS OF FIVE MAMMALSJournal of Histochemistry & Cytochemistry, 1973