Signal transduction and cell‐type specific regulation of matrix metalloproteinase gene expression: Can MMPs be good for you?
- 24 July 2007
- journal article
- review article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 213 (2), 355-364
- https://doi.org/10.1002/jcp.21208
Abstract
An abundance of literature over the past several years indicates a growing interest in the role of matrix metalloproteinases (MMPs) in normal physiology and in disease pathology. MMPs were originally defined by their ability to degrade the extracellular matrix, but it is now well documented that their substrates extend far beyond matrix components. Recent reviews discuss the structure and function of the MMP family members, as well as the promoter sequences that control gene expression. Thus, we focus on the signal transduction pathways that confer differential cell‐type expression of MMPs, as well as on some novel non‐matrix degrading functions of MMPs, particularly their intracellular location where they may contribute to apoptosis. In addition, increasing data implicate MMPs as “good guys”, protective agents in some cancers and in helping to resolve acute pathologic conditions. Despite the intricate and complicated roles of MMPs in physiology and pathology, the goal of designing therapeutics that can selectively target MMPs remains a major focus. Developing MMP inhibitors with targeted specificity will be difficult; success will depend on understanding the role of these enzymes in homeostasis and on the careful delineation of mechanisms by which this family of enzymes mediates disease pathology. J. Cell. Physiol. 213: 355–364, 2007.Keywords
This publication has 89 references indexed in Scilit:
- EGF‐R regulates MMP function in fibroblasts through MAPK and AP‐1 pathwaysJournal of Cellular Physiology, 2007
- RelA is required for IL-1β stimulation of Matrix Metalloproteinase-1 expression in chondrocytesOsteoarthritis and Cartilage, 2007
- Matrix metalloproteinases and the regulation of tissue remodellingNature Reviews Molecular Cell Biology, 2007
- Regulation of matrix metalloproteinase gene expression by a retinoid X receptor–specific ligandArthritis & Rheumatism, 2007
- The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancerBritish Journal of Cancer, 2007
- Matrix Metalloproteinase 3 Is Present in the Cell Nucleus and Is Involved in ApoptosisThe American Journal of Pathology, 2006
- Short Hairpin RNA–Mediated Inhibition of Matrix Metalloproteinase-1 in MDA-231 Cells: Effects on Matrix Destruction and Tumor GrowthCancer Research, 2005
- Transforming Growth Factor-β Repression of Matrix Metalloproteinase-1 in Dermal Fibroblasts Involves Smad3Published by Elsevier ,2001
- Nuclear Factor κB Activity Is Essential for Matrix Metalloproteinase-1 and -3 Upregulation in Rabbit Dermal FibroblastsBiochemical and Biophysical Research Communications, 1999
- Regulating Expression of the Gene for Matrix Metalloproteinase-1 (Collagenase): Mechanisms that Control Enzyme Activity, Transcription, and mRNA StabilityCritical Reviews™ in Eukaryotic Gene Expression, 1996