REPORT OF A CASE SHOWING CONGENITAL DEFECTS, SHORT STATURE, RETARDED SEXUAL DEVELOPMENT AND NO URINARY GONADOTROPINS

Abstract

THE following case is presented because we believe that any differences and variations from the so-called “clear cut case” should be recorded in the literature. Case Report In December 1943, a Polish girl, S. S., 16½ years old, came to the Children's Endocrine Clinic with the complaint that she had not grown in height since the age of twelve, and that she had never menstruated nor had she developed any secondary sexual characteristics. The patient was the fifth in a family of six children. Her mother and four sisters all had a normal menstrual history and apparently were sexually well developed. There was no history of any gross endocrine dyscrasia in any of the immediate family. The patient had had the ordinary childhood diseases. She had been alert mentally and showed good progress at school. Her infantile developmental history pertaining to holding head erect, teething, sitting up, walking and talking, was normal. The patient thought that her linear growth from birth to the age of twelve years seemed to keep pace with that of her friends of similar age. At the age of twelve, however, she noted and was told that her growth had become retarded and soon it became stunted. She also noted that she failed to develop any sizable amount of breast tissue, that pubic or axillary hairs d d not appear, and that she never menstruated.