Changes in cardiac output and total peripheral resistance during development of renal hypertension in the rabbit: lack of confomity with the autoregulation theory.
- 1 November 1976
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 39 (5), 633-639
- https://doi.org/10.1161/01.res.39.5.633
Abstract
Serial measurements of cardiac output (CO), mean arterial pressure (MAP), heart rate, and total peripheral resistance (TPR), were made on unanesthetized rabbits with previously implanted Doppler flowmeters. After 2 days of control measurements the rabbits were subjected alternatively to bilateral renal cellophane wrapping (wrap group) or to sham operation and additional measurements were made 1, 2, 4, 8, 16, 25, and 32 days after operation. During the 1st week after operation changes in CO were identical in the wrap and sham-operated groups, with an overall increase to a value of 110% of control on day 4 (P less than 0.05). Thereafter CO fell gradually, reaching 75% of control by day 32 in the wrap group, but only 95% of control in the sham-operated group. When CO was expressed per unit of body weight the latter differences were somewhat reduced, but still were significant. In wrap animals MAP and TPR rose progressively to 155% and 194% of control by day 32. In the sham-operated group the corresponding increases to 108% and 118% of control were significantly smaller. The MAP and TPR of the renal wrap rabbits exceeded the values in sham-operated rabbits, even over the 1st week after operation, by an average for MAP of 8.6 +/- 1.4% (P less than 0.001), and for TPR of 8.0 +/- 2.5% (P = 0.01). The results suggest that the changes in CO during the 1st week were a nonspecific consequence of the preceding wrap or sham operation. They bore no apparent relationship to the subsequent development of the hypertension which was "resistance-mediated" from the earliest stages. We conclude that the present findings for the rabbit differ from those reported for other species and do not conform to the changes predicted by the autoregulation theory of the pathogenesis of hypertension.This publication has 13 references indexed in Scilit:
- Estimation of non-autonomic and autonomic components of iliac bed vascular resistance in renal hypertensive rabbitsCardiovascular Research, 1975
- A comparison between thermodilution, electromagnetic and Doppler methods for cardiac output measurement in the rabbitClinical and Experimental Pharmacology and Physiology, 1974
- Contribution of cardiac output and peripheral resistance to experimental renal hypertensionAmerican Journal of Physiology-Legacy Content, 1974
- Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive RatsScience, 1973
- Pathogenesis of Arterial Hypertension after the Constriction of the Renal Artery Leaving the opposite Kidney Intact Both in the Anaesthetized and in the Conscious DogClinical Science, 1972
- Effect in the Conscious Dog of Constriction of the Renal Artery to a Sole Remaining Kidney on Haemodynamics, Sodium Balance, Body Fluid Volumes, Plasma Renin Concentration and Pressor Responsiveness to AngiotensinClinical Science, 1970
- Plasma Volume and Chronic HypertensionArchives of Internal Medicine, 1970
- THE ROLE OF THE HEART IN THE PATHOGENESIS OF RENAL HYPERTENSIONThe Lancet, 1963