Novel developments with the PRINTS protein fingerprint database
- 1 January 1997
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 25 (1), 212-216
- https://doi.org/10.1093/nar/25.1.212
Abstract
The PRINTS database of protein family 'fingerprints' is a diagnostic resource that complements the PROSITE dictionary of sites and patterns. Unlike regular expressions, fingerprints exploit groups of conserved motifs within sequence alignments to build characteristic signatures of family membership. Thus fingerprints inherently offer improved diagnostic reliability by virtue of the mutual context provided by motif neighbours. To date, 600 fingerprints have been constructed and stored in PRINTS, representing a 50% increase in the size of the database in the last year. The current version, 13.0, encodes approximately 3000 motifs, covering a range of globular and membrane proteins, modular polypeptides, and so on. The database is accessible via UCL's Bioinformatics World Wide Web (WWW) server at http://www.biochem.ucl.ac.uk/bsm/dbbrowser / . We describe here progress with the database, its Web interface, and a recent exciting development: the integration of a novel colour alignment editor (http://www.biochem.ucl.ac.uk/bsm/dbbrowser++ +/CINEMA ), which allows visualisation and interactive manipulation of PRINTS alignments over the Internet.Keywords
This publication has 25 references indexed in Scilit:
- DbBrowser: integrated access to databases worldwideTrends in Biochemical Sciences, 1996
- XFINGER: A tool for searching and visualising protein fingerprints and patternsBioinformatics, 1996
- Modular arrangement of proteins as inferred from analysis of homologyProtein Science, 1994
- Fingerprinting G-protein-coupled receptorsProtein Engineering, Design and Selection, 1994
- PRINTS–a protein motif fingerprint databaseProtein Engineering, Design and Selection, 1994
- Structure and sequence relationships in the lipocalins and related proteinsProtein Science, 1993
- ADSP–a new package for computational sequence analysisBioinformatics, 1992
- Proto-vav and gene expressionNature, 1992
- Mouse oncogene protein 24p3 is a member of the Lipocalin protein familyBiochemical and Biophysical Research Communications, 1991
- SOMAP: a novel interactive approach to multiple protein sequences alignmentBioinformatics, 1991