Absorption Kinetics of Hydroflumethiazide
- 1 April 1978
- journal article
- research article
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 18 (4), 190-193
- https://doi.org/10.1002/j.1552-4604.1978.tb01592.x
Abstract
The pharmacokinetics of hydroflumethiazide after oral administration of a 100-mg dose to 12 volunteers were evaluated to determine whether absorption of the drug is best described by zero-order or 1st-order absorption. Comparison of the 2 absorption models was based on 3 criteria: correlation coefficients; SD of the parameter estimates; and visual fits. Evaluation of the individual results in the light of each criterion showed that the zero-order absorption model is more appropriate for describing the hydroflumethiazide data.This publication has 6 references indexed in Scilit:
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